Animal Models of Proliferative Vitreoretinopathy and Their Use in Pharmaceutical Investigations
نویسندگان
چکیده
منابع مشابه
Proliferative vitreoretinopathy.
PURPOSE. The migration, proliferation, differentiation, and adhesion of cells and other cellular functions are influenced by the surrounding extracellular matrix, in normal and wound-healing conditions. The matrix metalloproteinases (MMPs) are a family of enzymes that degrade and remodel the extracellular matrix and, thus, play a central role in the wound-healing process. Proliferative vitreore...
متن کاملUse of perfluorocarbon liquids in proliferative vitreoretinopathy: results and complications.
BACKGROUND The present study was set up to evaluate the influence of perfluorocarbon liquids on the postoperative anatomical and functional results as well as on the complication rates in eyes with proliferative vitreoretinopathy (PVR). METHODS Sixty five consecutive eyes (64 patients) with PVR in different stages requiring surgical intervention where liquid perfluorocarbons were used were co...
متن کاملApoptosis in proliferative vitreoretinopathy.
PURPOSE To study the involvement of apoptosis using different apoptosis markers in PVR pathogenesis. METHODS The presence of mRNA coding for Fas, Fas ligand (FasL), and TNF-related apoptosis inducing ligand (TRAIL) was investigated in vitreous samples from 46 consecutive patients-25 with PVR, 11 with retinal detachment (RD) not complicated by PVR, and 10 with macular hole (MH)-using RT-PCR. F...
متن کاملKeratinocyte transglutaminase in proliferative vitreoretinopathy.
PURPOSE Proliferative vitreoretinopathy (PVR) is an excessive wound-healing process and the major complication in rhegmatogenous retinal detachment. The present study was designed to investigate the expression of keratinocyte transglutaminase (kTgase) in PVR membranes and retinal pigment epithelial (RPE) cells and to evaluate its expression in response to growth factors known to be increased in...
متن کاملProliferative Vitreoretinopathy and Genetic Profile
Proliferative vitreoretinopathy (PVR) is the principal cause of failure in retinal detachment (RD) surgery and is characterized by the proliferation of different cell types leading to the formation of cellular membranes on both sides of the retina. These membranes have the capability of contracture resulting in retinal redetachment. Despite marked improvement in vitreoretinal surgical technique...
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ژورنال
عنوان ژورنال: Ophthalmic Research
سال: 2018
ISSN: 0030-3747,1423-0259
DOI: 10.1159/000488492